The OC3 is an international consortium of cohort studies whose mission is to address scientific aims important for understanding ovarian cancer risk, early detection, tumor heterogeneity, and prognosis. The OC3 is part of the NCI Cohort Consortium, which is an extramural-intramural partnership to address the need for large-scale collaborations and provides the super-structure (but not funding) for managing the OC3. The OC3 currently has 28 participating, on-going cohort studies and we expect there to be over 8,000 invasive ovarian cancer cases among more than 1.5 million women. The goals of the OC3 are to bring together cohorts with ovarian cancer endpoints for pooled projects, build a focused group of ovarian cancer researchers, and develop a comprehensive approach that integrates questionnaire and pathology data with biomarkers, genetics, and tissue.
Trabert, B., Tworoger, S. S., O'Brien, K. M., Townsend, M. K., Fortner, R. T., Iversen, E. S., . . . Wentzensen, N. (2020). The risk of ovarian cancer increases with an increase in the lifetime number of ovulatory cycles: an analysis from the Ovarian Cancer Cohort Consortium (OC3). Cancer Res. doi:10.1158/0008-5472.CAN-19-2850
O'Brien, K. M., Tworoger, S. S., Harris, H. R., Anderson, G. L., Weinberg, C. R., Trabert, B., . . . Wentzensen, N. (2020). Association of Powder Use in the Genital Area With Risk of Ovarian Cancer. JAMA, 323(1), 49-59. doi:10.1001/jama.2019.20079
Huang, T., Townsend, M. K., Wentzensen, N., Trabert, B., White, E., Arslan, A. A., . . . Tworoger, S. S. (2019). Reproductive and Hormonal Factors and Risk of Ovarian Cancer by Tumor Dominance: Results from the Ovarian Cancer Cohort Consortium (OC3). Cancer Epidemiol Biomarkers Prev. doi:10.1158/1055-9965.EPI-19-0734